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STS-135 Research Chemical Compound.

STS-135 is more formally known as naphthalen-1-yl(9-pentyl-9H-carbazol-3-yl)methanone or N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA, and its molecular formula is C28H25NO. Its λmax can be 219, 234, 277, 299 or 340 nm, and its overall stability is rated at two years. STS-135 has a reputation as a designer drug, and is often sold as a cannabimimetic, or an artificial cannabinoid.

The design and origin of STS-135 is not reliably known, but its structure places it among the indole cannabimimetics. It seems to share many structure-activity features with this class of chemicals. In the same way that AM-2201 is an analogue of JWH-018 and XLR-11 is analogous to UR-144 (thought terminally fluorinated), STS is an analogue of the well-known SDB-001.

It is also considered an analogue of JWH-018, in that they both feature a naphthoyl group and show aminoalkylindole moiety. STS-35 differs with a benzene ring placed between the napthoyl group and the aminoalkylindole group.

Chemical Data and Identifiers:

IUPAC: N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide

CAS: 1354631-26-7

Molecular Formula: C24H31FN2O

Molecular Weight: 382.51

Form: Powder

As one would expect, In vitro STS-135 appears to be a powerful agonist for human cannabinoid receptors. It has an EC50 of 13 nM for the CB1 receptor and 51nM for the CB2. In vivo, STS-135 has been seen to produce both hypothermia and bradycardia in rats when administered at one to ten mg per kilo of subject weight, which is exactly what one would expect for a cannabinoid. The toxicological and physiological effects of this substance are not otherwise known. As such, STS-135 is intended only for research and forensic purposes, and is not suitable for human or animal consumption.


Legal Status:STS-135 is listed on the Forendex website among drugs with the potential for abuse. A forensic standard of the material is available. This is a relatively new entry in the field of synthetic cannabinoids, though, and it is not known to be a controlled substance in any country or territory.

STS-135 is not suitable for human consumption, and is sold only for research and forensic use in a laboratory environment.

For further information please visit Wikipedia page.