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PX-2 Research Chemical Substance.

PX-2, also known as 5F-APP-PINACA and FU-PX, is formally known as (S)-N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide.Its molecular formula is C22H25FN4O2It has an λmax of 209, 302 nM and a stability rating for two years.

Like PX-1, PX-2 is a fairly new compound, and so is not thoroughly understood on a chemical level. It is gaining in popularity as older CNB compounds like AB-CHMINACA are slowly falling out of favour. PX-2 is a potent artificial cannabinoid with Ki values similar to those of its analogue, 5-fluoro AB-PINACA for both the central CB1 peripheral CB2 receptors. PX-2 based on 5FAB-PINACA, but can be differentiated by the missing isopropyl group, which has been replaced with a benzyl group instead.

PX-2 is one of the indole family of cannabinoids, just like 5FAB-PINACA and AB-CHMINACA. These often analogous compounds have come to public (and official) attention lately as the active ingredients in common marijuana replacements and ‘legal highs’, especially in Japan ad New Zealand. 

PX-2 should be shipped on ice in the US and other temperate climates. More care may be needed in tropical climates.


Special Characteristics of PX-2:

Human Effects

Dosages of PX-2, presuming a lack of acquired tolerance

  • Threshold:  less than 1 mg
  • Light: approx. 1 to 1.5 mg
  • Standard: 1.5 to 2.5 mg
  • Strong: 2.5 to 3.5 mg
  • Heavy: 4+ mg 

Duration, one to two hours, as follows:

  • Onset: 10 to 20 minutes
  • Peak: 40 minutes to 1 hour
  • Offset: 20 to 30 minutes
  • Afterglow: 10 to 20 minutes

 Cognitive effects

  • Improved focus and mental state
  • Hyper-connected thought
  • Changes in time sense
  • Deeper, more conceptual thinking
  • Altered information processing
  • Unusual dream activity
  • Mild Anxiety

Physical effects of PX-2

  • ‘Tingles’ and tactile effects
  • Gentle sedation
  • Slowed motor control
  • Enhanced or reduced appetite
  • Mild Dehydration

Legal Status

Sweden Public Health Agency began efforts to classify PX-2 as a hazardous substance in 2014.

PX-2 can be found on the Fifth Schedule of the Misuse of Drugs Act in Singapore, and is illegal there.

In China PX-2 has been banned on October 1th 2015.

For further info please visit Wikipedia page.