You have no items in your shopping cart.

Buy dissociatives from doctorchemistry - What are dissociatives?

Dissociatives are a class of hallucinogens which are characterised by their ability to distort the perception in particular ways. In addition to changing one’s perceptions of sight and sound, they make you feel detached (‘dissociated’) either from the work around you, from your body, or both.

 How do dissociatives work?

Though the mechanisms differ from substance to substance, the majority of dissociatives work by either blocking or severely reducing the communication between the areas of the brain responsible for the conscious mind from the other parts of the brain. Most act as NMDA receptor antagonists, limiting the brain’s ability to communicate both with the body and between its various regions.

Hallucinations and hallucinatory effects are frequent side effects of dissociatives. These might include sensory hallucinations, a dream or trance-like state, or even total sensory deprivation.  It is believed that this is due to the lack of information flowing between brain regions – faced with a lack of stimulation, the different parts of the brain ‘fill in the gaps’ with dreamlike imagery and experiences.

 Selective dissociatives

A small subset of dissociatives are considered to be ‘highly selective’, meaning that they have a much stronger effect on the parts of the brain responsible for the dissociative state than for other, non-related neural receptors.

 Non-selective dissociatives

Most dissociatives, though, are not strongly selective. Many have powerful effects on the opioid and / or dopamine receptors, and produce greater or lesser degrees of euphoria as well as the dissociative state. They also tend to have similar side effects to opioids, including analgesia, anaesthesia, sedation, amnesia, ataxia and (perhaps most dangerous) respiratory depression.

 Effects of dissociatives

This is a fairly broad category of substances, each of which works in slightly different ways, so there is no ‘hard and fast list of effects’. That being said, though, the group is defined by its effects rather than by its structure or mechanism, so there are many held in common by most dissociatives.

Some (but not all) common effects for dissociatives include:

  • Sensory Dissociation (obviously)
  • Anaesthesia without loss of consciousness
  • Hallucination
  • Depersonalisation
  • Derealisation
  • Mania
  • Catalepsy
  • Analgesia
  • Amnesia

Like most psychoactive substances, the effects of many dissociatives are highly dosage-dependent. There is a distinction between an ‘anaesthetic dose’ and a ‘sub-anaesthetic’ dose, with the lower dosage more commonly producing the hallucinogenic or psychedelic effects. 

 The Recreational Use of Dissociatives

Many dissociatives and their nearest derivatives are considered illegal or semi-legal in the United States, the EU and many other parts of the world due to their long history of recreational use and abuse.

Ketamine (Quaalude) and nitrous oxide gas are both common dissociatives, and are still used as ‘club drugs’ today. Phencyclidine (PCP) is still sold on the street, and is rather infamous for its deleterious effects.

Other substances are not illegal per-se, but are misused to enhance their dissociative effect. Both chloroform and ether were considered ‘party drugs’ historically, and DXM (Dextromethorphan) containing cough syrup is often take in a much higher than recommended dosage to trigger its dissociative side effects deliberately.

 List of common dissociative chemicals

  • PCP
  • Ketamine
  • MXE
  • DXM
  • 3-MeO-PCP
  • Nitrous Oxide
  • Diethyl ether


There are no products matching the selection.

Our Priority