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5FAB-PINACA Research Chemical Substance.

5FAB-PINACA is also called 5-fluoro AB-PINACA and (S)-N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide, and its molecular formula is C18H26N4O2. Its λmax is listed as 210 and 303 nm and has a stability of two years.

Please note, 5FAB-PINACA is not to be confused with 5F-APINACA.

5FAB-PINACA is one of the indazole family of synthetic cannabinoids, all of which were derived from compounds developed for use as analgesics by Pfiser in 2009 but never approved for human use. It exhibits a powerful agonistic action on both the CB1 and CB2 receptors of humans, with an EC50 value of .48nm for the CB1 receptor and 2.6 nM for the CB2 receptor. Its metabolism is well described in medical literature.

It is derived from AB-PINACA, which came to official attention in 2012 as part of many prohibited cannabis substitutes sold in Japan and New Zealand. It is considered a medium-strength CB agonist, ranking above STS-135 and 2NE1 but below 5F-AKB48. Unconfirmed, anecdotal observations rate it substantially more potent than standard AB-PINACA.

From a structural standpoint, 5FAB-PINACA begins with an indazole structure much like other JWH derivatives. However, it is differentiated by using an indolyl base. It is a by-product of the very similar AB-PINACA but is distinguished by a fluorine molecule near the terminal carbon of the pentyl group.

Physically, 5FAB-PINACA is an off-white powder with a fine crystalline grain. It has no particular smell or taste.

Legal Status

5F-AB-PINACA is illegal in Germany as an Anlage II controlled substance, as of May 2015.

5-fluoro AB-PINACA is present on the Fifth Schedule of the Misuse of Drugs Act in Singapore as of May 2015, and illegal there as well.

It is distinct from AB-PINACA, which was prohibited in Japan in 2012 and China after 1th October.

The toxicology and pharmacology of this material is not yet fully understood.