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IUPAC: 1-(5-Fluoro-pentyl)-1H-indazole-3-carboxylic acid naphthalen-1-yl ester

CAS: 99312-12-2

Molecular Formula: C23H21FN2O2

Molecular Weight: 376.42

Form: Powder


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Buy online 5F-SDB-005 from doctorchemistry.

5F-SDB-005 is also known as naphthalen-1-yl 1-(5-fluoropentyl)-1H-indazole-3-carboxylate, and has a chemical formula of C23H21FN2O2.  Its λmax is listed as 221, 302 nm and it has a stability of approximately 2 years.

5F-SDB-005 is one of a family of synthetic cannabinoids which are structurally similar to THJ-2201. The main difference between 5F SDB and THJ-2201is the fact that 5F-SDB-005 has an aryl naphthyl group (which itself has a naphthyl ester) at the indazole 3 position.

5F-SDB-005 has also been described as an analogue of SDB-006, which is an n-alkylindole which features an amide linking the 3 position with an additional benzyl group. 5F-SDB-005 can be differentiated in that it uses a benzyl substituent proximal to the amide linker, as opposed to a phenyl group.

5F-SDB-005 is an analogue to SDB-005. Both are synthetic cannabinoids that activate the central CB1 receptor preferentially to the peripheral CB2 receptor (The EC50 is 21 nM for the CB1 receptor, and 140 nM for CB2).

Toxicological and pharmacological data have not been heavily reported for this chemical. Whilst some of this compound’s properties are unknown, we do know that the presence of a fluorine on the alkyl chain’s terminal carbon in other, similar cannabimimetic agents usually increases affinity for both CB1 and CB2 receptors significantly in humans.


It has been observed that cannabinoids that have an aromatic ester will eventually degrade (through transesterification) when stored in alcohol-based solvents at room temperature. Therefore, we recommend using aprotic solvents such as acetonitrile for this entire structural class of compounds.


5F-SDB-005 can be shipped at room temperature in temperate climates, but may need special protections in warmer climates.

This product is not suitable for human consumption, and is sold only for research and forensic use in a laboratory environment.

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