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5F-AMB Research Chemical Substance.

5F-AMB is also known as 5F-AMB-PINACA, (R)-methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate and (S)-methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate, and has a molecular formula of C19H26FN3O3. Its λmax is 209 and 301 nm, and its stability is rated at approximately two years.

5F-AMB is one of the indazole-based artifical cannabinoids of the indazole-3-carboxamide type. It is quite commonly used as the primary active ingredient in cannabis substitutes around the world. There is little precise pharmacological information available about 5F-AMB as it was only identified in early 2014.5F-AMB does have a closely related analogue, 4-cyanobutyl, which is known to be a very potent agonist for the CB1 receptor, with a Ki of 0.7 nM.

5F-AMB is an analogous derivative of AB-PINACA, one of the synthetic cannabinoids that so recently gained attention for their presence in illicit herbal products in several countries around the world.


Special Characteristics of 5F-AMB:

Latest Research

Recently, ChemAxon and ACD/Labs investigated 5F-AMB. They provided a tentative topological analysis including the following:

  • Asymmetric Atom Count: 1
  • Atom count: 50
  • Bond Count: 51
  • Chain Atom Count: 15
  • Chain Bond Count: 15
  • Cyclomatic Number: 2
  • Rotatable Bond Count: 8


The research suggested something of its geometrical structure, showing:

  • Deriding Energy: 60.79 kcal/mol
  • Volume:  319.04?3
  • Minimal Projection Area: 63.62?2
  • Maximum Projection Area: 99.93?2
  • Polar Surface Area: 90.01
  • Molecular surface area: 535.17


5F-AMB is a controlled substance listed in in Germany’s Anlage II and illegal there.

It is a banned substance in China on October 1th 2015.

The public health agency of Sweden was in favour of classifying 5F-AMB hazardous as of November 10, 2014.

The US as a whole has no position on 5F-AMB, but the state of Louisiana banned it in June of 2014.

5F-AMB is illegal in Singapore, according to the Fifth Schedule of the Misuse of Drugs Act.

For further information please visit Wikipedia page.